N55S (p.Asn55Ser) variant of LCK (Tyrosine-protein kinase Lck)
N55S (p.Asn55Ser) in LCK (Tyrosine-protein kinase Lck) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.09 / 1. The record also includes population frequency data, experimental measurements, and structural context.
N55S (p.Asn55Ser) variant details
- p.Asn55Ser
- ExAC rs776547244
- gnomAD rs776547244
- Missense
- Variant Prioritization Score for Impact Estimate 0.0891
- REVEL 0.02
- CADD 4.28
- PolyPhen-2 0.00
- SIFT 1.00
- Most common in the South Asian population (allele frequency 0.001)
- Structural context available
- LCK SH3 domain domainome 1.0: score -0.261