N40K (p.Asn40Lys) variant of LCK (Tyrosine-protein kinase Lck)
N40K (p.Asn40Lys) in LCK (Tyrosine-protein kinase Lck) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.12 / 1. The record also includes population frequency data, experimental measurements, published literature, and structural context.
N40K (p.Asn40Lys) variant details
- p.Asn40Lys
- gnomAD 1-32274751-T-A
- Missense
- Variant Prioritization Score for Impact Estimate 0.118
- REVEL 0.02
- CADD 13.80
- PolyPhen-2 0.02
- SIFT 0.65
- Most common in the Non-Finnish European population (allele frequency 9.1e-07)
- Structural context available
- LCK SH3 domain domainome 1.0: score -0.862
- Literature evidence available