M14I (p.Met14Ile) variant of LCK (Tyrosine-protein kinase Lck)
M14I (p.Met14Ile) in LCK (Tyrosine-protein kinase Lck) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.28 / 1. The record also includes population frequency data, experimental measurements, published literature, and structural context.
M14I (p.Met14Ile) variant details
- p.Met14Ile
- gnomAD 1-32274371-G-A
- Missense
- Variant Prioritization Score for Impact Estimate 0.276
- REVEL 0.09
- CADD 17.80
- PolyPhen-2 0.00
- SIFT 1.00
- Most common in the South Asian population (allele frequency 1.2e-05)
- Structural context available
- LCK SH3 domain domainome 1.0: score -0.165
- Literature evidence available