L37I (p.Leu37Ile) variant of LCK (Tyrosine-protein kinase Lck)
L37I (p.Leu37Ile) in LCK (Tyrosine-protein kinase Lck) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.16 / 1. The record also includes population frequency data, experimental measurements, published literature, and structural context.
L37I (p.Leu37Ile) variant details
- p.Leu37Ile
- gnomAD 1-32274740-C-A
- Missense
- Variant Prioritization Score for Impact Estimate 0.157
- REVEL 0.02
- CADD 6.02
- PolyPhen-2 0.01
- SIFT 0.50
- Population evidence available
- Structural context available
- LCK SH3 domain domainome 1.0: score -0.177
- Literature evidence available