L36R (p.Leu36Arg) variant of LCK (Tyrosine-protein kinase Lck)
L36R (p.Leu36Arg) in LCK (Tyrosine-protein kinase Lck) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.30 / 1. The record also includes population frequency data, experimental measurements, and structural context.
L36R (p.Leu36Arg) variant details
- p.Leu36Arg
- ExAC rs755220816
- gnomAD rs755220816
- Missense
- Variant Prioritization Score for Impact Estimate 0.297
- REVEL 0.18
- CADD 16.10
- PolyPhen-2 0.01
- SIFT 0.69
- Most common in the Non-Finnish European population (allele frequency 8.2e-06)
- Structural context available
- LCK SH3 domain domainome 1.0: score -0.0739