L36P (p.Leu36Pro) variant of LCK (Tyrosine-protein kinase Lck)
L36P (p.Leu36Pro) in LCK (Tyrosine-protein kinase Lck) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.30 / 1. The record also includes population frequency data, experimental measurements, published literature, and structural context.
L36P (p.Leu36Pro) variant details
- p.Leu36Pro
- gnomAD 1-32274738-T-C
- Missense
- Variant Prioritization Score for Impact Estimate 0.298
- REVEL 0.17
- CADD 18.20
- PolyPhen-2 0.00
- SIFT 0.36
- Most common in the Non-Finnish European population (allele frequency 9.1e-07)
- Structural context available
- LCK SH3 domain domainome 1.0: score -0.0739
- Literature evidence available