L30P (p.Leu30Pro) variant of LCK (Tyrosine-protein kinase Lck)
L30P (p.Leu30Pro) in LCK (Tyrosine-protein kinase Lck) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.26 / 1. The record also includes population frequency data, experimental measurements, and structural context.
L30P (p.Leu30Pro) variant details
- p.Leu30Pro
- ExAC rs749818114
- TOPMed rs749818114
- gnomAD rs749818114
- Missense
- Variant Prioritization Score for Impact Estimate 0.263
- REVEL 0.13
- CADD 23.10
- PolyPhen-2 0.09
- SIFT 0.22
- Most common in the Non-Finnish European population (allele frequency 9e-07)
- Structural context available
- LCK SH3 domain domainome 1.0: score -0.362