I38V (p.Ile38Val) variant of LCK (Tyrosine-protein kinase Lck)
I38V (p.Ile38Val) in LCK (Tyrosine-protein kinase Lck) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.04 / 1. The record also includes population frequency data, experimental measurements, published literature, and structural context.
I38V (p.Ile38Val) variant details
- p.Ile38Val
- gnomAD 1-32274743-A-G
- Missense
- Variant Prioritization Score for Impact Estimate 0.0443
- REVEL 0.02
- CADD 2.44
- PolyPhen-2 0.00
- SIFT 0.48
- Population evidence available
- Structural context available
- LCK SH3 domain domainome 1.0: score -0.714
- Literature evidence available