I17M (p.Ile17Met) variant of LCK (Tyrosine-protein kinase Lck)
I17M (p.Ile17Met) in LCK (Tyrosine-protein kinase Lck) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.12 / 1. The record also includes population frequency data, experimental measurements, and structural context.
I17M (p.Ile17Met) variant details
- p.Ile17Met
- ExAC rs751726470
- gnomAD rs751726470
- Missense
- Variant Prioritization Score for Impact Estimate 0.12
- REVEL 0.08
- CADD 14.80
- PolyPhen-2 0.33
- SIFT 0.08
- Most common in the African/African-American population (allele frequency 3e-05)
- Structural context available
- LCK SH3 domain domainome 1.0: score 0.228