I17F (p.Ile17Phe) variant of LCK (Tyrosine-protein kinase Lck)
I17F (p.Ile17Phe) in LCK (Tyrosine-protein kinase Lck) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.25 / 1. The record also includes population frequency data, experimental measurements, published literature, and structural context.
I17F (p.Ile17Phe) variant details
- p.Ile17Phe
- gnomAD 1-32274378-A-T
- Missense
- Variant Prioritization Score for Impact Estimate 0.252
- REVEL 0.08
- CADD 21.30
- PolyPhen-2 0.00
- SIFT 0.27
- Most common in the REMAINING population (allele frequency 1.7e-05)
- Structural context available
- LCK SH3 domain domainome 1.0: score 0.228
- Literature evidence available