H8Y (p.His8Tyr) variant of LCK (Tyrosine-protein kinase Lck)
H8Y (p.His8Tyr) in LCK (Tyrosine-protein kinase Lck) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.23 / 1. The record also includes population frequency data, experimental measurements, and structural context.
H8Y (p.His8Tyr) variant details
- p.His8Tyr
- ExAC rs763977216
- gnomAD rs763977216
- Missense
- Variant Prioritization Score for Impact Estimate 0.233
- REVEL 0.12
- CADD 16.80
- PolyPhen-2 0.00
- SIFT 0.10
- Most common in the Non-Finnish European population (allele frequency 1.8e-06)
- Structural context available
- LCK SH3 domain domainome 1.0: score -0.0285