G53S (p.Gly53Ser) variant of LCK (Tyrosine-protein kinase Lck)
G53S (p.Gly53Ser) in LCK (Tyrosine-protein kinase Lck) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.32 / 1. The record also includes population frequency data, experimental measurements, and structural context.
G53S (p.Gly53Ser) variant details
- p.Gly53Ser
- gnomAD rs1443973811
- Missense
- Variant Prioritization Score for Impact Estimate 0.317
- REVEL 0.05
- CADD 17.30
- PolyPhen-2 0.04
- SIFT 0.66
- Most common in the South Asian population (allele frequency 1.2e-05)
- Structural context available
- LCK SH3 domain domainome 1.0: score 0.148