G53R (p.Gly53Arg) variant of LCK (Tyrosine-protein kinase Lck)
G53R (p.Gly53Arg) in LCK (Tyrosine-protein kinase Lck) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.34 / 1. The record also includes population frequency data, experimental measurements, published literature, and structural context.
G53R (p.Gly53Arg) variant details
- p.Gly53Arg
- gnomAD 1-32274788-G-C
- Missense
- Variant Prioritization Score for Impact Estimate 0.342
- REVEL 0.09
- CADD 19.20
- PolyPhen-2 0.00
- SIFT 0.32
- Most common in the South Asian population (allele frequency 1.2e-05)
- Structural context available
- LCK SH3 domain domainome 1.0: score 0.148
- Literature evidence available