G4S (p.Gly4Ser) variant of LCK (Tyrosine-protein kinase Lck)
G4S (p.Gly4Ser) in LCK (Tyrosine-protein kinase Lck) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.29 / 1. The record also includes population frequency data, experimental measurements, published literature, and structural context.
G4S (p.Gly4Ser) variant details
- p.Gly4Ser
- gnomAD 1-32274339-G-A
- Missense
- Variant Prioritization Score for Impact Estimate 0.286
- REVEL 0.08
- CADD 13.90
- PolyPhen-2 0.00
- SIFT 0.92
- Population evidence available
- Structural context available
- LCK SH3 domain domainome 1.0: score -0.0334
- Literature evidence available