G34D (p.Gly34Asp) variant of LCK (Tyrosine-protein kinase Lck)
G34D (p.Gly34Asp) in LCK (Tyrosine-protein kinase Lck) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.18 / 1. The record also includes population frequency data, experimental measurements, and structural context.
G34D (p.Gly34Asp) variant details
- p.Gly34Asp
- NCI-TCGA Cosmic COSV1002
- cosmic curated COSV10028
- Ensembl rs1640192059
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.177
- REVEL 0.09
- CADD 7.91
- PolyPhen-2 0.00
- SIFT 0.65
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the East Asian population (allele frequency 2.5e-05)
- Structural context available
- LCK SH3 domain domainome 1.0: score -0.0257