G32S (p.Gly32Ser) variant of LCK (Tyrosine-protein kinase Lck)
G32S (p.Gly32Ser) in LCK (Tyrosine-protein kinase Lck) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.14 / 1. The record also includes population frequency data, experimental measurements, published literature, and structural context.
G32S (p.Gly32Ser) variant details
- p.Gly32Ser
- gnomAD 1-32274423-G-A
- Missense
- Variant Prioritization Score for Impact Estimate 0.137
- REVEL 0.03
- CADD 18.10
- PolyPhen-2 0.00
- SIFT 0.85
- Most common in the Non-Finnish European population (allele frequency 1.8e-06)
- Structural context available
- LCK SH3 domain domainome 1.0: score -0.0823
- Literature evidence available