G32D (p.Gly32Asp) variant of LCK (Tyrosine-protein kinase Lck)
G32D (p.Gly32Asp) in LCK (Tyrosine-protein kinase Lck) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.21 / 1. The record also includes population frequency data, experimental measurements, published literature, and structural context.
G32D (p.Gly32Asp) variant details
- p.Gly32Asp
- gnomAD 1-32274424-G-A
- Missense
- Variant Prioritization Score for Impact Estimate 0.212
- REVEL 0.06
- CADD 19.90
- PolyPhen-2 0.01
- SIFT 0.63
- Most common in the REMAINING population (allele frequency 1.7e-05)
- Structural context available
- LCK SH3 domain domainome 1.0: score -0.0823
- Literature evidence available