E52K (p.Glu52Lys) variant of LCK (Tyrosine-protein kinase Lck)
E52K (p.Glu52Lys) in LCK (Tyrosine-protein kinase Lck) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.24 / 1. The record also includes population frequency data, experimental measurements, and structural context.
E52K (p.Glu52Lys) variant details
- p.Glu52Lys
- NCI-TCGA Cosmic COSV6073
- cosmic curated COSV60738
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.24
- REVEL 0.13
- CADD 20.50
- PolyPhen-2 0.00
- SIFT 0.37
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the REMAINING population (allele frequency 3.3e-05)
- Structural context available
- LCK SH3 domain domainome 1.0: score -0.311