E21K (p.Glu21Lys) variant of LCK (Tyrosine-protein kinase Lck)
E21K (p.Glu21Lys) in LCK (Tyrosine-protein kinase Lck) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.38 / 1. The record also includes population frequency data, experimental measurements, published literature, and structural context.
E21K (p.Glu21Lys) variant details
- p.Glu21Lys
- gnomAD 1-32274390-G-A
- Missense
- Variant Prioritization Score for Impact Estimate 0.38
- REVEL 0.12
- CADD 24.20
- PolyPhen-2 0.02
- SIFT 0.11
- Population evidence available
- Structural context available
- LCK SH3 domain domainome 1.0: score -0.415
- Literature evidence available