E21D (p.Glu21Asp) variant of LCK (Tyrosine-protein kinase Lck)
E21D (p.Glu21Asp) in LCK (Tyrosine-protein kinase Lck) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.14 / 1. The record also includes population frequency data, experimental measurements, published literature, and structural context.
E21D (p.Glu21Asp) variant details
- p.Glu21Asp
- gnomAD 1-32274392-G-C
- Missense
- Variant Prioritization Score for Impact Estimate 0.142
- REVEL 0.04
- CADD 15.80
- PolyPhen-2 0.01
- SIFT 0.34
- Population evidence available
- Structural context available
- LCK SH3 domain domainome 1.0: score -0.415
- Literature evidence available