E10A (p.Glu10Ala) variant of LCK (Tyrosine-protein kinase Lck)
E10A (p.Glu10Ala) in LCK (Tyrosine-protein kinase Lck) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.28 / 1. The record also includes population frequency data, experimental measurements, published literature, and structural context.
E10A (p.Glu10Ala) variant details
- p.Glu10Ala
- gnomAD 1-32274358-A-C
- Missense
- Variant Prioritization Score for Impact Estimate 0.282
- REVEL 0.06
- CADD 22.50
- PolyPhen-2 0.01
- SIFT 0.13
- Most common in the Non-Finnish European population (allele frequency 9e-07)
- Structural context available
- LCK SH3 domain domainome 1.0: score -0.019
- Literature evidence available