D46N (p.Asp46Asn) variant of LCK (Tyrosine-protein kinase Lck)
D46N (p.Asp46Asn) in LCK (Tyrosine-protein kinase Lck) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.35 / 1. The record also includes population frequency data, experimental measurements, published literature, and structural context.
D46N (p.Asp46Asn) variant details
- p.Asp46Asn
- gnomAD 1-32274767-G-A
- Missense
- Variant Prioritization Score for Impact Estimate 0.348
- REVEL 0.07
- CADD 22.80
- PolyPhen-2 0.01
- SIFT 0.22
- Most common in the Non-Finnish European population (allele frequency 9e-07)
- Structural context available
- LCK SH3 domain domainome 1.0: score -0.317
- Literature evidence available