D31H (p.Asp31His) variant of LCK (Tyrosine-protein kinase Lck)
D31H (p.Asp31His) in LCK (Tyrosine-protein kinase Lck) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.36 / 1. The record also includes population frequency data, experimental measurements, published literature, and structural context.
D31H (p.Asp31His) variant details
- p.Asp31His
- gnomAD 1-32274420-G-C
- Missense
- Variant Prioritization Score for Impact Estimate 0.36
- REVEL 0.07
- CADD 24.40
- PolyPhen-2 0.46
- SIFT 0.14
- Most common in the South Asian population (allele frequency 1.2e-05)
- Structural context available
- LCK SH3 domain domainome 1.0: score -0.234
- Literature evidence available