D31G (p.Asp31Gly) variant of LCK (Tyrosine-protein kinase Lck)
D31G (p.Asp31Gly) in LCK (Tyrosine-protein kinase Lck) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.27 / 1. The record also includes population frequency data, experimental measurements, and structural context.
D31G (p.Asp31Gly) variant details
- p.Asp31Gly
- gnomAD rs1342708327
- Missense
- Variant Prioritization Score for Impact Estimate 0.274
- REVEL 0.10
- CADD 23.40
- PolyPhen-2 0.06
- SIFT 0.44
- Most common in the Latino/Admixed American population (allele frequency 2.2e-05)
- Structural context available
- LCK SH3 domain domainome 1.0: score -0.234