D18N (p.Asp18Asn) variant of LCK (Tyrosine-protein kinase Lck)
D18N (p.Asp18Asn) in LCK (Tyrosine-protein kinase Lck) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.39 / 1. The record also includes population frequency data, experimental measurements, and structural context.
D18N (p.Asp18Asn) variant details
- p.Asp18Asn
- ExAC rs755284744
- TOPMed rs755284744
- gnomAD rs755284744
- Missense
- Variant Prioritization Score for Impact Estimate 0.386
- REVEL 0.13
- CADD 25.00
- PolyPhen-2 0.04
- SIFT 0.05
- Most common in the African/African-American population (allele frequency 4.8e-05)
- Structural context available
- LCK SH3 domain domainome 1.0: score -0.725