D12G (p.Asp12Gly) variant of LCK (Tyrosine-protein kinase Lck)
D12G (p.Asp12Gly) in LCK (Tyrosine-protein kinase Lck) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.33 / 1. The record also includes population frequency data, experimental measurements, published literature, and structural context.
D12G (p.Asp12Gly) variant details
- p.Asp12Gly
- gnomAD 1-32274364-A-G
- Missense
- Variant Prioritization Score for Impact Estimate 0.331
- REVEL 0.14
- CADD 23.00
- PolyPhen-2 0.01
- SIFT 0.05
- Most common in the Non-Finnish European population (allele frequency 1.8e-06)
- Structural context available
- LCK SH3 domain domainome 1.0: score -0.525
- Literature evidence available