D11N (p.Asp11Asn) variant of LCK (Tyrosine-protein kinase Lck)
D11N (p.Asp11Asn) in LCK (Tyrosine-protein kinase Lck) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.30 / 1. The record also includes population frequency data, experimental measurements, and structural context.
D11N (p.Asp11Asn) variant details
- p.Asp11Asn
- NCI-TCGA Cosmic COSV1002
- cosmic curated COSV10028
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.3
- REVEL 0.06
- CADD 23.80
- PolyPhen-2 0.00
- SIFT 0.01
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the Non-Finnish European population (allele frequency 9e-07)
- Structural context available
- LCK SH3 domain domainome 1.0: score -0.363