C5Y (p.Cys5Tyr) variant of LCK (Tyrosine-protein kinase Lck)
C5Y (p.Cys5Tyr) in LCK (Tyrosine-protein kinase Lck) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.45 / 1. The record also includes population frequency data, experimental measurements, published literature, and structural context.
C5Y (p.Cys5Tyr) variant details
- p.Cys5Tyr
- gnomAD 1-32274343-G-A
- Missense
- Variant Prioritization Score for Impact Estimate 0.454
- REVEL 0.26
- CADD 23.10
- PolyPhen-2 0.03
- SIFT 0.22
- Most common in the East Asian population (allele frequency 2.5e-05)
- Structural context available
- LCK SH3 domain domainome 1.0: score 0.0971
- Literature evidence available