C3S (p.Cys3Ser) variant of LCK (Tyrosine-protein kinase Lck)
C3S (p.Cys3Ser) in LCK (Tyrosine-protein kinase Lck) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.58 / 1. The record also includes population frequency data, experimental measurements, and structural context.
C3S (p.Cys3Ser) variant details
- p.Cys3Ser
- Ensembl rs1640189479
- Missense
- Variant Prioritization Score for Impact Estimate 0.576
- REVEL 0.41
- CADD 28.10
- PolyPhen-2 1.00
- SIFT 0.00
- Most common in the REMAINING population (allele frequency 3.3e-05)
- Structural context available
- LCK SH3 domain domainome 1.0: score -0.113