C3F (p.Cys3Phe) variant of LCK (Tyrosine-protein kinase Lck)
C3F (p.Cys3Phe) in LCK (Tyrosine-protein kinase Lck) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.61 / 1. The record also includes population frequency data, experimental measurements, published literature, and structural context.
C3F (p.Cys3Phe) variant details
- p.Cys3Phe
- gnomAD 1-32274337-G-T
- Missense
- Variant Prioritization Score for Impact Estimate 0.614
- REVEL 0.47
- CADD 29.40
- PolyPhen-2 1.00
- SIFT 0.00
- Most common in the Non-Finnish European population (allele frequency 9e-07)
- Structural context available
- LCK SH3 domain domainome 1.0: score -0.113
- Literature evidence available