A58P (p.Ala58Pro) variant of LCK (Tyrosine-protein kinase Lck)
A58P (p.Ala58Pro) in LCK (Tyrosine-protein kinase Lck) is a protein-truncating change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.22 / 1. The record also includes population frequency data, experimental measurements, published literature, and structural context.
A58P (p.Ala58Pro) variant details
- p.Ala58Pro
- gnomAD 1-32274292-GA-G
- Frameshift
- Variant Prioritization Score for Impact Estimate 0.219
- CADD 8.40
- Population evidence available
- Structural context available
- LCK SH3 domain domainome 1.0: score -0.536
- Literature evidence available