Y75C (p.Tyr75Cys) variant of LCAT (P04180)
Y75C (p.Tyr75Cys) in LCAT (P04180) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.58 / 1. The record also includes population frequency data and structural context.
Y75C (p.Tyr75Cys) variant details
- p.Tyr75Cys
- ExAC rs749574144
- TOPMed rs749574144
- gnomAD rs749574144
- Missense
- Variant Prioritization Score for Impact Estimate 0.579
- REVEL 0.61
- CADD 24.30
- PolyPhen-2 0.97
- SIFT 0.08
- Most common in the African/African-American population (allele frequency 2.4e-05)
- Structural context available