L10P (p.Leu10Pro) variant of LAMC2 (Laminin subunit gamma-2)
L10P (p.Leu10Pro) in LAMC2 (Laminin subunit gamma-2) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.36 / 1. The record also includes population frequency data, published literature, and structural context.
L10P (p.Leu10Pro) variant details
- p.Leu10Pro
- gnomAD 1-183186381-T-C
- Missense
- Variant Prioritization Score for Impact Estimate 0.356
- REVEL 0.22
- CADD 26.70
- PolyPhen-2 0.55
- SIFT 0.01
- Most common in the African/African-American population (allele frequency 0.00031)
- Structural context available
- Literature evidence available