D100Y (p.Asp100Tyr) variant of LAMB3 (Laminin subunit beta-3)
D100Y (p.Asp100Tyr) in LAMB3 (Laminin subunit beta-3) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.47 / 1. The record also includes structural context.
D100Y (p.Asp100Tyr) variant details
- p.Asp100Tyr
- rs1347157076
- NCI-TCGA Cosmic COSV6191
- cosmic curated COSV61914
- TOPMed rs1347157076
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.472
- AlphaMissense 0.20
- MetaLR 0.46
- MetaSVM -0.19
- PolyPhen-2 1.00
- SIFT 0.01
- MutPred 0.52
- UniProt: Variant assessed as somatic; moderate impact.
- Structural context available