R59P (p.Arg59Pro) variant of KRT9 (Keratin, type I cytoskeletal 9)
R59P (p.Arg59Pro) in KRT9 (Keratin, type I cytoskeletal 9) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.39 / 1. The record also includes population frequency data and structural context.
R59P (p.Arg59Pro) variant details
- p.Arg59Pro
- rs778678852
- ExAC rs778678852
- TOPMed rs778678852
- gnomAD rs778678852
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.387
- REVEL 0.47
- CADD 16.50
- PolyPhen-2 0.08
- SIFT 0.04
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the African/African-American population (allele frequency 0.00012)
- Structural context available