G74D (p.Gly74Asp) variant of KRT9 (Keratin, type I cytoskeletal 9)
G74D (p.Gly74Asp) in KRT9 (Keratin, type I cytoskeletal 9) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.38 / 1. The record also includes population frequency data and structural context.
G74D (p.Gly74Asp) variant details
- p.Gly74Asp
- NCI-TCGA Cosmic COSV5585
- TOPMed rs1907096227
- gnomAD rs1907096227
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.383
- REVEL 0.39
- CADD 16.80
- PolyPhen-2 0.58
- SIFT 0.00
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the South Asian population (allele frequency 1.2e-05)
- Structural context available