L98I (p.Leu98Ile) variant of KRT8 (Keratin, type II cytoskeletal 8)
L98I (p.Leu98Ile) in KRT8 (Keratin, type II cytoskeletal 8) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.81 / 1. The record also includes population frequency data and structural context.
L98I (p.Leu98Ile) variant details
- p.Leu98Ile
- TOPMed rs1331169400
- gnomAD rs1331169400
- Missense
- Variant Prioritization Score for Impact Estimate 0.808
- CADD 29.60
- PolyPhen-2 0.90
- SIFT 0.00
- Most common in the HGDP:BURUSHO population (allele frequency 0.042)
- Structural context available