I106T (p.Ile106Thr) variant of KRT8 (Keratin, type II cytoskeletal 8)
I106T (p.Ile106Thr) in KRT8 (Keratin, type II cytoskeletal 8) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.61 / 1. The record also includes population frequency data and structural context.
I106T (p.Ile106Thr) variant details
- p.Ile106Thr
- NCI-TCGA Cosmic COSV5317
- cosmic curated COSV53179
- gnomAD rs1941466105
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.614
- CADD 25.50
- PolyPhen-2 0.25
- SIFT 0.00
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the African/African-American population (allele frequency 0.00012)
- Structural context available