R69T (p.Arg69Thr) variant of KRT6B (Keratin, type II cytoskeletal 6B)
R69T (p.Arg69Thr) in KRT6B (Keratin, type II cytoskeletal 6B) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.27 / 1. The record also includes population frequency data and structural context.
R69T (p.Arg69Thr) variant details
- p.Arg69Thr
- TOPMed rs914504608
- gnomAD rs914504608
- Missense
- Variant Prioritization Score for Impact Estimate 0.269
- REVEL 0.17
- CADD 23.00
- PolyPhen-2 0.09
- SIFT 0.02
- Most common in the African/African-American population (allele frequency 0.00031)
- Structural context available