G89S (p.Gly89Ser) variant of KRT6B (Keratin, type II cytoskeletal 6B)
G89S (p.Gly89Ser) in KRT6B (Keratin, type II cytoskeletal 6B) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.28 / 1. The record also includes population frequency data and structural context.
G89S (p.Gly89Ser) variant details
- p.Gly89Ser
- TOPMed rs1433215826
- Missense
- Variant Prioritization Score for Impact Estimate 0.282
- REVEL 0.05
- CADD 16.60
- PolyPhen-2 0.01
- SIFT 0.19
- Most common in the African/African-American population (allele frequency 0.00041)
- Structural context available