G99R (p.Gly99Arg) variant of KRT6A (Keratin, type II cytoskeletal 6A)
G99R (p.Gly99Arg) in KRT6A (Keratin, type II cytoskeletal 6A) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.62 / 1. The record also includes population frequency data and structural context.
G99R (p.Gly99Arg) variant details
- p.Gly99Arg
- NCI-TCGA Cosmic COSV1004
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.619
- REVEL 0.59
- CADD 22.40
- PolyPhen-2 0.14
- SIFT 0.04
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the 1KG:MXL population (allele frequency 0.0081)
- Structural context available