G74W (p.Gly74Trp) variant of KRT6A (Keratin, type II cytoskeletal 6A)
G74W (p.Gly74Trp) in KRT6A (Keratin, type II cytoskeletal 6A) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.51 / 1. The record also includes population frequency data and structural context.
G74W (p.Gly74Trp) variant details
- p.Gly74Trp
- gnomAD rs1224623328
- Missense
- Variant Prioritization Score for Impact Estimate 0.509
- REVEL 0.60
- CADD 24.70
- PolyPhen-2 0.96
- SIFT 0.01
- Most common in the South Asian population (allele frequency 1.2e-05)
- Structural context available