G65W (p.Gly65Trp) variant of KRT6A (Keratin, type II cytoskeletal 6A)
G65W (p.Gly65Trp) in KRT6A (Keratin, type II cytoskeletal 6A) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.47 / 1. The record also includes population frequency data and structural context.
G65W (p.Gly65Trp) variant details
- p.Gly65Trp
- rs1376405967
- TOPMed rs1376405967
- gnomAD rs1376405967
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.466
- REVEL 0.49
- CADD 23.90
- PolyPhen-2 0.96
- SIFT 0.00
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the Non-Finnish European population (allele frequency 8.8e-05)
- Structural context available