S26F (p.Ser26Phe) variant of KRT5 (Keratin, type II cytoskeletal 5)
S26F (p.Ser26Phe) in KRT5 (Keratin, type II cytoskeletal 5) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.45 / 1. The record also includes population frequency data and structural context.
S26F (p.Ser26Phe) variant details
- p.Ser26Phe
- NCI-TCGA Cosmic COSV5286
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.453
- REVEL 0.34
- CADD 25.40
- PolyPhen-2 0.56
- SIFT 0.00
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the Non-Finnish European population (allele frequency 9e-07)
- Structural context available