F115S (p.Phe115Ser) variant of KRT5 (Keratin, type II cytoskeletal 5)
F115S (p.Phe115Ser) in KRT5 (Keratin, type II cytoskeletal 5) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.19 / 1. The record also includes population frequency data and structural context.
F115S (p.Phe115Ser) variant details
- p.Phe115Ser
- TOPMed rs1262403815
- gnomAD rs1262403815
- Missense
- Variant Prioritization Score for Impact Estimate 0.186
- REVEL 0.07
- CADD 19.90
- PolyPhen-2 0.00
- SIFT 0.40
- Most common in the African/African-American population (allele frequency 4.9e-05)
- Structural context available