P105S (p.Pro105Ser) variant of KRT4 (Keratin, type II cytoskeletal 4)
P105S (p.Pro105Ser) in KRT4 (Keratin, type II cytoskeletal 4) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.56 / 1. The record also includes population frequency data and structural context.
P105S (p.Pro105Ser) variant details
- p.Pro105Ser
- gnomAD rs1440646814
- Missense
- Variant Prioritization Score for Impact Estimate 0.561
- REVEL 0.41
- CADD 23.80
- PolyPhen-2 0.90
- SIFT 0.02
- Most common in the Finnish in Finland (FIN) population (allele frequency 0.00091)
- Structural context available