G98S (p.Gly98Ser) variant of KRT4 (Keratin, type II cytoskeletal 4)
G98S (p.Gly98Ser) in KRT4 (Keratin, type II cytoskeletal 4) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.43 / 1. The record also includes population frequency data and structural context.
G98S (p.Gly98Ser) variant details
- p.Gly98Ser
- ExAC rs749433758
- gnomAD rs749433758
- Missense
- Variant Prioritization Score for Impact Estimate 0.429
- REVEL 0.32
- CADD 21.60
- PolyPhen-2 0.51
- SIFT 0.18
- Most common in the African/African-American population (allele frequency 0.00041)
- Structural context available