G75R (p.Gly75Arg) variant of KRT4 (Keratin, type II cytoskeletal 4)
G75R (p.Gly75Arg) in KRT4 (Keratin, type II cytoskeletal 4) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.71 / 1. The record also includes population frequency data and structural context.
G75R (p.Gly75Arg) variant details
- p.Gly75Arg
- TOPMed rs111875720
- Missense
- Variant Prioritization Score for Impact Estimate 0.709
- REVEL 0.67
- CADD 22.90
- PolyPhen-2 1.00
- SIFT 0.08
- Most common in the Non-Finnish European population (allele frequency 2.9e-05)
- Structural context available