G28V (p.Gly28Val) variant of KRT4 (Keratin, type II cytoskeletal 4)
G28V (p.Gly28Val) in KRT4 (Keratin, type II cytoskeletal 4) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.17 / 1. The record also includes population frequency data and structural context.
G28V (p.Gly28Val) variant details
- p.Gly28Val
- NCI-TCGA Cosmic COSV5340
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.173
- REVEL 0.17
- CADD 0.31
- PolyPhen-2 0.00
- SIFT 0.38
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the South Asian population (allele frequency 1.2e-05)
- Structural context available