F89S (p.Phe89Ser) variant of KRT4 (Keratin, type II cytoskeletal 4)
F89S (p.Phe89Ser) in KRT4 (Keratin, type II cytoskeletal 4) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.29 / 1. The record also includes population frequency data and structural context.
F89S (p.Phe89Ser) variant details
- p.Phe89Ser
- ESP rs370214897
- ExAC rs370214897
- TOPMed rs370214897
- gnomAD rs370214897
- Missense
- Variant Prioritization Score for Impact Estimate 0.294
- REVEL 0.24
- CADD 18.90
- PolyPhen-2 0.01
- SIFT 0.33
- Most common in the HGDP:MAKRANI population (allele frequency 0.023)
- Structural context available